Effect of the Carboxyl-Terminal Tripeptide of Vasopressin on Plasma Free Fatty Acids and Cyclic Adenosine Monophosphate in Man

K. Raij Dept. of Clinical Chemistry, University of Helsinki, Meilahti Hospital, Helsinki, Finland, and Ferring AB, Malmö, Sweden

M. Harkonen Dept. of Clinical Chemistry, University of Helsinki, Meilahti Hospital, Helsinki, Finland, and Ferring AB, Malmö, Sweden

J. Mulder Dept. of Clinical Chemistry, University of Helsinki, Meilahti Hospital, Helsinki, Finland, and Ferring AB, Malmö, Sweden

H. Adlercreutz Dept. of Clinical Chemistry, University of Helsinki, Meilahti Hospital, Helsinki, Finland, and Ferring AB, Malmö, Sweden

Abstract

The carboxyl-terminal tripeptide of vasopressin (Pro-Arg-Gly. NH₂) and adrenocorticotrophic hormone (ACTH) were injected intravenously into six human subjects, and the effects of these peptides on plasma free fatty acids (FFA) and cAMP concentrations were compared with that of saline. Twenty μg of the tripetide and 100 μg of ACTH increased the plasma FFA concentration to the same extent, whereas 200 μg of the tripetide was without this lipolytic effect. ACTH and the smaller dose of the tripeptide elevated the plasma cAMP level only in the same two subjects.

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Effect of the Carboxyl-Terminal Tripeptide of Vasopressin on Plasma Free Fatty Acids and Cyclic Adenosine Monophosphate in Man

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Effect of the Carboxyl-Terminal Tripeptide of Vasopressin on Plasma Free Fatty Acids and Cyclic Adenosine Monophosphate in Man

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