Normal Arterial Blood Gases during Experimental Hypertriglyceridemia in the Rat

Abstract

The possible effect of high concentrations of plasma triglycerides on arterial oxygen tension was investigated in rats by infusion of lymph chylomicrons or a soybean oil emulsion (Intralipid®). Mean triglyceride concentrations were raised from 130 to 1454 mg/100 ml without statistically significant change in arterial oxygen tension, oxygen saturation, carbon dioxide tension, or pH. The small reductions in arterial oxygen tension, content, or saturation observed in earlier studies may have been due to inadequate stabilization of the fat emulsion then available for intravenous use. The present data suggest that high concentrations of plasma triglycerides produced by infusion of chylomicrons or Intralipid do not affect arterial blood gases in the normal rat.

Key Words:

• Hyperlipidemia
• lipids
• oxygen
• parenteral feeding
• triglycerides