Radioimmunoassay of Human Calcitonin in Serum and Tissue from Healthy Individuals and Patients with Medullary Carcinoma of the Thyroid Gland

Thyroid Gland Institute of Physiology, University of Oslo, Dept. of Surgical Research, Rikshospitalet; and The Norwegian Radiumhospital, Oslo, Norway

K. M. Gautvik Institute of Physiology, University of Oslo, Dept. of Surgical Research, Rikshospitalet; and The Norwegian Radiumhospital, Oslo, Norway

Trine Normann Institute of Physiology, University of Oslo, Dept. of Surgical Research, Rikshospitalet; and The Norwegian Radiumhospital, Oslo, Norway

Vigdis Teig Institute of Physiology, University of Oslo, Dept. of Surgical Research, Rikshospitalet; and The Norwegian Radiumhospital, Oslo, Norway

S. O. Wille Institute of Physiology, University of Oslo, Dept. of Surgical Research, Rikshospitalet; and The Norwegian Radiumhospital, Oslo, Norway

I. O. Brennhovd Institute of Physiology, University of Oslo, Dept. of Surgical Research, Rikshospitalet; and The Norwegian Radiumhospital, Oslo, Norway

Ingrid Christensen Institute of Physiology, University of Oslo, Dept. of Surgical Research, Rikshospitalet; and The Norwegian Radiumhospital, Oslo, Norway

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Abstract

A specific radioimmunological method for measurement of immunoreactive calcitonin (iCT) in human serum and tissue is described. Of healthy individuals of both sexes, 85% had measurable iCT in serum (mean, 0.23 ng/ ml). Of 29 patients who had received treatment for medullary carcinoma of the thyroid gland (MCT), 19 had increased serum iCT (0.60 ng/ml to 205 ng/ ml). Elevated serum iCT was also found preoperatively in 2 MCT patients. Eleven of the patients with abnormal elevations of serum iCT were alive 4 to 13 years after the operation. Concentration of iCT in extracts from MCT varied from 0.5 to 540 ng/ml wet weight. The diagnostic value of this method and its importance for pre- and post-operative evaluation of these patients are improved by the use of selective venous catheterization in basal state and during stimulation of CT secretion.

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Radioimmunoassay of Human Calcitonin in Serum and Tissue from Healthy Individuals and Patients with Medullary Carcinoma of the Thyroid Gland

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Radioimmunoassay of Human Calcitonin in Serum and Tissue from Healthy Individuals and Patients with Medullary Carcinoma of the Thyroid Gland

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