Principles of albumin and IgG analyses in neurological disorders. II. Relation of the concentration of the proteins in serum and cerebrospinal fluid

Abstract

A total of 116 patients were subgrouped according to the presence of neurological disorder and abnormal S-albumin, S-IgG, S-haptoglobin and S-CRP. Abnormal serum protein concentrations were registered in 21 % of patients with neurological symptoms but no signs of organic neurological disorder, and in 58% of patients with various neurological disorders except multiple sclerosis. Increased S-IgG and S-haptoglobin were most common. The CSF/S albumin ratio is proposed to be a more sensitive and adequate parameter for the demonstration of a blood-brain damage than CSF-protein or CSF-albumin. In patients with serum protein abnormalities the CSF IgG/protein and CSF IgG/albumin ratios were increased in 28% and 44% of the patients without organic neurological disease and in 40% and 51% of the patients with neurological disorders except multiple sclerosis. The IgG-index = (CSF/S IgG ratio)/(CSF/S albumin ratio) was elevated only in 8% and 15%. The IgG-index is a better measure for IgG synthesis within the CNS than the other two.

Key Words:

• CSF-albumin
• CSF-IgG
• IgG-index
• neurological disorders
• serum proteins