Increased plasma cyclic AMP concentrations in fasting man

O. D. Mjøs Department of Physiology, Institute of Medical Biology and Department of Medicine, Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway

H. Vik-Mo Department of Physiology, Institute of Medical Biology and Department of Medicine, Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway

T. Henden Department of Physiology, Institute of Medical Biology and Department of Medicine, Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway

H. Wang Department of Physiology, Institute of Medical Biology and Department of Medicine, Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway

Abstract

Plasma concentrations of adenosine 3′, 5′ monophosphate (cyclic AMP), free fatty acids (FFA), glycerol and glucose were measured after 24, 48 and 72 h fasting in healthy male students. There was a marked rise in plasma concentrations of cyclic AMP, FFA and glycerol from 24 to 48 h fasting with no further changes from 48 to 72 h fasting. Plasma glucose concentrations fell. After 72 h fasting, inhibition of adipose tissue lipolysis with a nicotinic acid analogue effected no significant change in plasma cyclic AMP concentrations, indicating that the elevated plasma nucleotide concentrations during fasting were not related to stimulation of lipolysis.

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Increased plasma cyclic AMP concentrations in fasting man

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Increased plasma cyclic AMP concentrations in fasting man

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