[⁵¹Cr] EDTA plasma clearance and endogenous creatinine clearance in advanced renal insufficiency

U. G. Svendsen Department of Clinical Physiology and Medicine B (Nephrology), Herlev Hospital, University of Copenhagen, Herlev, Denmark

O. Munck Department of Clinical Physiology and Medicine B (Nephrology), Herlev Hospital, University of Copenhagen, Herlev, Denmark

A. Czartoryski Department of Clinical Physiology and Medicine B (Nephrology), Herlev Hospital, University of Copenhagen, Herlev, Denmark

G. Stafanger Department of Clinical Physiology and Medicine B (Nephrology), Herlev Hospital, University of Copenhagen, Herlev, Denmark

Abstract

Comparison of [51Cr]EDTA plasma clearance corrected for extrarenal elimination with 24 h endogenous creatinine clearance in patients with advanced renal failure showed that the corrected [51Cr]EDTA clearance was lower than creatinine clearance, and thus might be a better approximation to the glomerular nitration rate in uraemic patients. The corrections cannot be used on [5 CrJEDTA clearance values below the mean extrarenal clearance, averaging 3.7 ml/min.

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[⁵¹Cr] EDTA plasma clearance and endogenous creatinine clearance in advanced renal insufficiency

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[51Cr] EDTA plasma clearance and endogenous creatinine clearance in advanced renal insufficiency

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[⁵¹Cr] EDTA plasma clearance and endogenous creatinine clearance in advanced renal insufficiency