11
Views
10
CrossRef citations to date
0
Altmetric
Original

The kinetics of myoglobin in old volunteers and in patients with acute myocardial infarction

Pages 561-565 | Received 06 Dec 1977, Accepted 11 May 1978, Published online: 07 Apr 2011
 

Abstract

Following pre-treatment with potassium iodide, [125I]myoglobin was administered intravenously to six old volunteers. Blood and urine samples were taken at regular intervals. Serum radioactivity was shown to be myoglobin-bound. Three rates of elimination were observed, with half-lives of 20 min, 3 h 20 min, and 18 h 30 min. The first two rates corresponded to distribution volumes of 5.2 and 211. The third rate was of zero order and had eliminated around 10% of administered radioactivity after 6 h. At this time 60% of administered radioactivity had been recovered from the urine. Around 80% appeared as non-protein bound 125I, while 10% was protein-bound. The latter fraction was not precipitable with antiserum against myoglobin, which suggests that this fraction was deconjugated globin. Only insignificant amounts were excreted as myoglobin. The elimination constants were larger than those found in patients with acute myocardial infarction (AMI), measured by the disappearance rate of endogenous myoglobin.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.