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Original

Stimulation of heart rate by insulin: uninfluenced by β-adrenergic receptor blockade in rabbits

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Pages 253-256 | Received 07 Jul 1978, Accepted 20 Dec 1978, Published online: 14 Feb 2011
 

Abstract

Intravenous injection of insulin increased heart rate approximately 20% in six alloxan-diabetic rabbits. Blood glucose concentrations after insulin did not decrease below the fasting level of non-diabetic animals and none of the rabbits had signs of hypoglycermia. Intravenous injection of saline or insulin solvent had no effect on heart rate. The stimulatory effect of insulin on heart rate was not influenced by autonomic nervous blockade by propranolol or by propranolol plus atropine.

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