3
Views
0
CrossRef citations to date
0
Altmetric
Editorial Article

Serum lipoprotein and lymphocyte LDL receptor studies in parents and children with heterozygous familial hypercholesterolemia

, &
Pages 113-118 | Received 30 Jul 1981, Accepted 02 Nov 1981, Published online: 17 Mar 2010
 

Abstract

In certain cases heterozygous familial hypercholesterolaemia (FH) cannot be confidently diagnosed from elevated serum lipid and lipoprotein values alone because of overlap with normal values. In the present study, therefore, lymphocyte high-affinity LDL receptor degradation of 125I-LDL was measured in 36 subjects from nine FH families. In eight families there was a good agreement between elevated serum lipid and lipoprotein values and reduced 125I-LDL degradation. In the ninth family, however, LDL receptor activity was normal in three subjects from three generations with elevated serum lipids and lipoproteins. The data suggest a disorder of LDL metabolism other than FH.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.