Plasma concentrations of five proteinase inhibitors in healthy school-age children and in children with familial risk of ischaemic heart disease

Abstract

The plasma concentrations of five proteinase inhibitors (α₂-plasmin inhibitor, α₂-antitrypsin, antithrombin III, C1-inactivator, α₂-macroglobulin) in healthy school-age children were determined by electroimmunoassay. The concentrations of the same proteins were further determined in children with a familial risk of developing ischaemic heart disease. A significantly lower concentration of antithrombin III and a higher concentration of fibrinogen was found in this group.

Key-words:

• antithrombin III
• α₁-antitrypsin
• fibrinogen
• C1-inactivator
• ischaemic heart disease
• α₂-macroglobulin
• α₂-plasmin inhibitor
• reference interval