Trypsin-inhibitory activities of acid-stable fragments of the inter-alpha-trypsin inhibitor in inflammatory and uraemic conditions

Abstract

The concentration in serum of the acid-stable M_r 30.000 fragment of the Inter-alpha-Trypsin Inhibitor (SPI), and the acid-stable M_r 14.000 fragment of the inhibitor prepared by trypsin by digestion of the acid-precipitated serum proteins (API) was determined. A considerable increase in concentration of SPI and a decrease in concentration of API were observed in inflammatory conditions. In uraemic conditions the concentration of SPI was increased while that of API was unchanged.

Key Words:

• inflammation
• inter-alpha-trypsin inhibitor
• proteinase inhibitors
• trypsin inhibitors
• uraemia