Cardiovascular effects of secretin infusion in man

Abstract

Secretin infusion in man causes an increase in renal blood flow. The aim of the present study was to assess further the cardiovascular effects of the hormone. Secretin was infused at a rate of 2 CU/kg·h to patients with angina pectoris and normal left ventricular function. Cardiac output increased by an average of 20%, the stroke volume increased and the total systemic resistance decreased. Systemic arterial pressure, heart rate and pulmonary capillary wedge pressure were unaltered. The results are compatible with a combined inotropic and vasodilating effect of the hormone. It is concluded that secretin may have potential merits in the treatment of acute left ventricular failure.

Key-words:

• cardiac output
• cardiotonic agent
• haemodynamics
• secretin
• vasodilating agent