Lowered serum ionized calcium in insulin treated diabetic subjects

N. Fogh-Andersen Departments of Clinical Chemistry, Herlev, Glostrup, Hvidovre and Aalborg Hospitals. Diabetes Outpatient Clinic, Hvidøre Hospital, Denmark

P. McNair Departments of Clinical Chemistry, Herlev, Glostrup, Hvidovre and Aalborg Hospitals. Diabetes Outpatient Clinic, Hvidøre Hospital, Denmark

J. Møller-Petersen Departments of Clinical Chemistry, Herlev, Glostrup, Hvidovre and Aalborg Hospitals. Diabetes Outpatient Clinic, Hvidøre Hospital, Denmark

S. Madsbad Departments of Clinical Chemistry, Herlev, Glostrup, Hvidovre and Aalborg Hospitals. Diabetes Outpatient Clinic, Hvidøre Hospital, Denmark

Abstract

The concentration of ionized calcium at pH 7.40, [Ca²⁺]_7.4, in serum from 43 insulin dependent diabetic patients was lowered in comparison with 47 healthy controls (p < 0.001), and the difference was biggest in children under sixteen. Serum total calcium, phosphate, and parathyroid hormone were normal, and it is inexplicable why the parathyroid glands did not react by raising serum total calcium. The lowered serum ionized calcium may contribute to the development of diabetic bone loss.

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Lowered serum ionized calcium in insulin treated diabetic subjects

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Lowered serum ionized calcium in insulin treated diabetic subjects

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