Exercise stimulation in insulin-dependent diabetics, normal increase in albuminuria with abnormal blood pressure response

Abstract

Increased urinary albumin excretion rate (AER), microalbuminuria, has been regarded as a sign of incipient nephropathy. The influence of exercise on AER was investigated in 10 male type I diabetics and in 12 age-matched male controls. The duration of diabetes was 7–31 years (median 14 years). The exercise tests were performed both as a combined submaximal workload-waterload test and as a maximal workload test. Urinary albumin was measured with an ELISA technique. During exercise in both tests, no difference was seen in the AER between diabetics and their controls. However, the increase in systolic blood pressure was significantly more marked in the diabetics. There was no correlation between the blood pressure response during exercise and the AER, neither in the diabetics, nor in their controls. It is concluded, that. increased blood pressure response during exercise does not necessarily result in increased AER in type I diabetics.

Key words:

• diabetic nephropathy
• exercise
• incipient nephropathy
• systolic blood pressure
• type I diabetes
• urinary albumin excretion rate