Release of granulocyte elastase and complement changes during hysterectomy

Abstract

Complement activation and release of granulocyte elastase has been previously reported during major vascular surgery and has been ascribed to plasma/cell interactions with foreign surfaces or to administration of blood or plasma. The effect of uncomplicated general anaesthesia and surgery, not requiring blood or plasma, on complement activation and signs of proteinase release was assessed by measuring C₃d and elastase-alpha-1 PI, respectively, in nine patients undergoing elective hysterectomy.

There was a minor decrease in plasma C₃d during anaesthesia, surgery and in the post-operative period caused by the diluting effect of intravenous fluids. Elastase alpha-1 PI remained largely unchanged until the first post-operative day, when a significant increase was seen (p<0.05); on the second and third day significant elevated values were still observed.

Release of granulocyte elastase seems to be a generalized response to surgical trauma and may be a part of the endocrine-metabolic stress response.

Key Words:

• anaesthesia
• complement
• elastase
• leukocytes
• surgery