Some aspects of structural studies on aspartic proteinases

Abstract

This paper gives a brief overview over the differences and similarities in the structure of aspartic proteinases presently available. Comparison of the three-dimentional stucture of different aspartic proteinases by a common intramolecular coordinate system have been performed. The intramolecular movable subdomains have been localized and the role of motion in substrate binding and zymogen activation is discussed.

Key Words:

• aspartic proteinases
• EC 3.4.23
• pepsin
• X-ray
• structure