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Original Article

Central venous oxygen saturation during hypovolaemic shock in humans

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Pages 67-72 | Received 26 Feb 1992, Accepted 11 Sep 1992, Published online: 29 Mar 2011
 

Abstract

Madsen P, Iversen H, Seeker NH. Central venous oxygen saturation during hypovolaemic shock in humans. Scand J Clin Lab Invest 1993; 53: 67-72.

We compared central venous oxygen saturation and central venous pressure (CVP) as indices of the effective blood volume during 50° head-up tilt (anti-Trendelenburg's position) induced hypovolaemic shock in eight healthy subjects. Head-up tilt increased thoracic electrical impedance from 31 (28-36) (median and range) to 34 (30-40) Ohm, mean arterial pressure (MAP) from 79 (70-88) to 86 (80-99) mmHg, heart rate (HR) from 67 (56-71) to 99 (78-119) beats min−1 (p<0.01) and total peripheral resistance (TPR) from 20 (16-32) to 36 (15-52) mmHg min l−l (p<0.03). Cardiac output decreased from 4.3 (3.0-4.8) to 2.7 (1.8-4.8) 1 min−1 (p<0.03). After 29 (9-56) min presyncopal symptoms appeared, together with a decrease in MAP to 63 (43-79) mmHg, HR to 68 (30-112) beats min−1 and TPR to 22 (13-33) mmHg min−1 (p<0.02). During tilting CVP decreased from 3 (1-6) to 1 (-3-5) mmHg (p<0.05) but thereafter remained stable. In contrast, central venous oxygen saturation showed a linear decrease with time from 0.75 (0.69-0.78) at rest to 0.60 (0.49-0.67) (p<0.01) when presyncopal symptoms appeared. Central venous catheterization is a tool for measurement of central venous oxygen saturation in addition to recording of CVP. The results suggest that a reduced central blood volume is reflected more clearly in central venous oxygen saturation than in CVP.

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