Calcium sensing receptor gene: Analysis of polymorphism frequency

L. A. Rubin Departments of Medicine, Clinical Biochemistry and Genetics, University of Toronto, Toronto

V. Peltekova Departments of Medicine, Clinical Biochemistry and Genetics, University of Toronto, Toronto

N. Janicic Departments of Physiology and Medicine, McGill University, Montreal, Canada

C. C. Liew Departments of Medicine, Clinical Biochemistry and Genetics, University of Toronto, Toronto

D. Hwang Departments of Medicine, Clinical Biochemistry and Genetics, University of Toronto, Toronto

J. Evrovski Departments of Medicine, Clinical Biochemistry and Genetics, University of Toronto, Toronto

G. N. Hendy Departments of Physiology and Medicine, McGill University, Montreal, Canada

D E.C. Cole Departments of Physiology and Medicine, McGill University, Montreal, Canada

show all

Abstract

The role that the Calcium Sensing Receptor (CASR) plays in extracellular calcium regulation had been ascertained through studies of inactivating as well as activating mutations of CASR gene in a number of multiplex families. We have extended these observations to a polymorphism analysis of the intercellular domain of CASR in a cohort of healthy young women. The results demonstrate significant allelic polymorphism as a result of nonconservative changes at two specific sites. Further studies will be required to determine what, if any, relationship this may have to CASR phenotype.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Calcium sensing receptor gene: Analysis of polymorphism frequency

Information for

Open access

Opportunities

Help and information

Calcium sensing receptor gene: Analysis of polymorphism frequency

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature