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Research Article

Evaluation of an ionized magnesium-pH analyzer-NOVA 8

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Pages 127-133 | Published online: 08 Jul 2009
 

Abstract

An ion - selective analyzer (NOVA 8 [previously NOVA CRT], NOVA Biomedical, Waltham, USA) for simultaneous measurement of the concentration of ionized magnesium (cMg2+) and pH is investigated for linearity and influence of calcium ions on the Mg2+ results in different Mg2+ aqueous solutions with/without added calcium. Within the cMg2+ range 0-3.0 mmol/L, which covers most clinical values, we found cMg2+ values close to the line of identity, with a sensitivity about 94%, but 0.09 mmol/L lower in the absence of Ca2+. The analytical precision (CV) for human serum control was 1.7% in the physiological range. The accuracy and precision data for the Mg2+ electrode meet the demands for reliable results within the range for clinical use. We found a reference interval (95%) for cMg2+ of between 0.43 and 0.59 mmol/L in serum, with a mean value of 0.51 mmol/L for healthy adults in the non - fasting state with no relation to sex or age. The mean cMg2+ was 61% of the mean concentration of plasma total magnesium (cTMg) ranging from (95%) 49% to 73%. No significant correlation was found between cMg2+ and total protein, albumin, phosphate, Ca2+, and total CO2. No significant difference was found between mean values for cMg2+ in whole blood, plasma, and serum. Serum samples could be stored for 24 h at 4%C without significant change. Storage at -20°C for 7 months caused a mean cMg2+

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