Carvastatin suppresses intimal thickening of rabbit carotid artery after balloon catheter injury probably through the inhibition of vascular smooth muscle cell proliferation and migration

M Komukai * The Second Department of Internal Medicine, School of Medicine, Chiba University,; Department of Bioscience Research, Senga Pharmaceutical Laboratory Inc., and

Y Saitoh-Wajima * The Second Department of Internal Medicine, School of Medicine, Chiba University,

J Tashiro * The Second Department of Internal Medicine, School of Medicine, Chiba University,

M Shinomiya Saiseikai-Funabashi Hospital, Tokyo, Japan; Department of Bioscience Research, Senga Pharmaceutical Laboratory Inc., and

Y Saito * The Second Department of Internal Medicine, School of Medicine, Chiba University,

N Morisaki * The Second Department of Internal Medicine, School of Medicine, Chiba University,

Abstract

In order to test whether a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor has an anti-atherogenic activity, the effects of carvastatin, a newly developed potent inhibitor, and pravastatin were examined on the intimal thickening of the artery after the endothelial denudation induced by balloon catheter injury. Rabbits were divided into four groups; control, pravastatin-treated (20 mg kg^-1 day^-1) and two of carvastatin-treated groups (10 or 20 mg kg^-1 day^-1

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Carvastatin suppresses intimal thickening of rabbit carotid artery after balloon catheter injury probably through the inhibition of vascular smooth muscle cell proliferation and migration

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Carvastatin suppresses intimal thickening of rabbit carotid artery after balloon catheter injury probably through the inhibition of vascular smooth muscle cell proliferation and migration

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