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Scandinavian Journal of Clinical and Laboratory Investigation Volume 59, 1999 - Issue 2
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Research Article

Aldosterone metabolism in cultures of rat renal cortical and medullary cells

M Egfjord Medical Department P, Division of Nephrology and Department of Experimental Pathology, Rigshospitalet, Copenhagen, Denmark
,
H-B Dahl Medical Department P, Division of Nephrology and Department of Experimental Pathology, Rigshospitalet, Copenhagen, Denmark
,
C Kayser Medical Department P, Division of Nephrology and Department of Experimental Pathology, Rigshospitalet, Copenhagen, Denmark
&
H Blæhr Medical Department P, Division of Nephrology and Department of Experimental Pathology, Rigshospitalet, Copenhagen, Denmark
Pages 107-113 | Published online: 08 Jul 2009
 
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Abstract

The metabolism of 4-14C-d-aldosterone (at 3 nM) was studied in the primary target organ of the hormone, in renal cortical and medullary cell cultures obtained from Wistar rats. Larger amounts of aldosterone were metabolized in medullary cells than in cortical cells, as measured by a decreased 4-14

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