Endothelin plays an important role in the endothelium-dependent vasodilatation in the human forearm

M Sarabi Departments of Internal Medicine and

J Millgård Departments of Internal Medicine and

A Hägg Departments of Internal Medicine and

P Ridefelt Surgery, University Hospital of Uppsala, Sweden;

J Henriksson Department of Physiology III3, Karolinska Institute, Stockholm, Sweden

L Lind Departments of Internal Medicine and

Abstract

Endothelium-dependent vasodilatation (EDV) in humans has been evaluated mainly by local infusion of a muscarinic-receptor agonists in the forearm. It has been postulated that the function of the vasodilator nitric oxide (NO) can be evaluated with this technique. However, the role of the vasoconstrictor endothelin in this model has not been investigated. Methods

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Endothelin plays an important role in the endothelium-dependent vasodilatation in the human forearm

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Endothelin plays an important role in the endothelium-dependent vasodilatation in the human forearm

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