Increased Levels of Specific Leukocyte- and Platelet-derived Substances during Normal Anti-tetanus Antibody Synthesis in Patients with Inactive Crohn Disease

Abstract

Background: Crohn disease is considered a consequence of inappropriate upregulation of immune reactions evoked by the intestinal microflora or luminal antigens. Since the intestinal mucosa is continuously exposed to tetanus toxoid we studied the antibody response to tetanus toxoid booster immunization in patients with Crohn disease and the subsequent release of various inflammatory mediators and growth factors in blood. Methods:

• Anti-TETANUS Antibodies Crohn Disease Crp Histamine Il-6 Mpo Pai-1 Tetanus Toxoid Timp-1 Tnf-ALPHA Vegf