Effect of Circulating Peptide YY on Gallbladder Emptying in Humans

Abstract

Background: To further establish its role in the ileal brake mechanism, we determined the effect of the distal gut hormone peptide YY (PYY) on gallbladder motility and plasma gut hormones during the cephalic phase of meal stimulation. Methods: Eight healthy volunteers were studied in a randomized crossover design, with or without intravenous infusion of a physiological dose of PYY. On each occasion, subjects underwent modified sham feeding followed by real feeding. Results:

• Cephalic Phase Cholecystokinin Pancreatic Polypeptide Sham Feeding