Ascites Fluid and Plasma Calprotectin Concentrations in Liver Disease

C. HomannDept. of Medical Gastroenterology C, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark; Clinic of Internal Medicine I, H:S Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark; Dept. of Rheumatology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark; Tissue Typing Laboratory of the Dept. of Clinical Immunology, National University Hospital, Rigshospitalet, Copenhagen Hospital Corporation, Copenhagen, DenmarkCorrespondence[email protected]

E. ChristensenDept. of Medical Gastroenterology C, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark; Clinic of Internal Medicine I, H:S Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark; Dept. of Rheumatology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark; Tissue Typing Laboratory of the Dept. of Clinical Immunology, National University Hospital, Rigshospitalet, Copenhagen Hospital Corporation, Copenhagen, Denmark

P. SchlichtingDept. of Medical Gastroenterology C, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark; Clinic of Internal Medicine I, H:S Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark; Dept. of Rheumatology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark; Tissue Typing Laboratory of the Dept. of Clinical Immunology, National University Hospital, Rigshospitalet, Copenhagen Hospital Corporation, Copenhagen, Denmark

E. K. PhilipsenDept. of Medical Gastroenterology C, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark; Clinic of Internal Medicine I, H:S Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark; Dept. of Rheumatology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark; Tissue Typing Laboratory of the Dept. of Clinical Immunology, National University Hospital, Rigshospitalet, Copenhagen Hospital Corporation, Copenhagen, Denmark

N. A. GraudalDept. of Medical Gastroenterology C, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark; Clinic of Internal Medicine I, H:S Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark; Dept. of Rheumatology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark; Tissue Typing Laboratory of the Dept. of Clinical Immunology, National University Hospital, Rigshospitalet, Copenhagen Hospital Corporation, Copenhagen, Denmark

P. GarredDept. of Medical Gastroenterology C, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark; Clinic of Internal Medicine I, H:S Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark; Dept. of Rheumatology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark; Tissue Typing Laboratory of the Dept. of Clinical Immunology, National University Hospital, Rigshospitalet, Copenhagen Hospital Corporation, Copenhagen, Denmark

Abstract

Background: Calprotectin, a marker of neutrophil activation, has been associated with a poor prognosis in alcohol-induced cirrhosis. The aims were to study concentrations of calprotectin in patients with various liver diseases, and to further investigate the prognostic value of calprotectin in cirrhosis. Methods: Plasma calprotectin concentrations were determined in 84 patients with alcohol-induced liver disease, 32 hepatitis B or C infected patients, 33 patients with liver disease of other aetiologies, 7 patients with combined aetiologies and in 24 patients with malignant disease. Thirty healthy individuals were included as controls. Ascites calprotectin concentrations were determined in patients with ascites (n = 75). Follow-up for survival was performed after a median observation period of 10 months. Results: Increased plasma and ascites calprotectin concentrations were observed in malignant disease compared to non-malignant disease (P < 0.0001). Plasma calprotectin concentrations were low in viral liver disease compared to patients with non-viral liver disease (P = 0.02) and to controls (P = 0.0002). Plasma calprotectin (>median) was a highly significant marker of poor survival in alcohol-induced cirrhosis (P = 0.001), but was of no prognostic value in non-alcohol-induced cirrhosis (P = 0.88). In decompensated cirrhosis high (>upper quartile) ascites calprotectin concentrations were associated with an increased mortality (P = 0.002), as were high (>median) plasma calprotectin levels (P = 0.009). Conclusion: The prognostic importance of calprotectin in alcohol-induced cirrhosis is confirmed and demonstrated as specific for alcohol-induced liver disease. Low calprotectin levels are indicated in viral liver disease, and an association between high ascites calprotectin levels and malignant ascites was observed.

Key words:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Ascites Fluid and Plasma Calprotectin Concentrations in Liver Disease

Information for

Open access

Opportunities

Help and information

Ascites Fluid and Plasma Calprotectin Concentrations in Liver Disease

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature