Effects of Calcium Infusion on Gastric Secretion in Heidenhain Pouch Dogs

M. MignonDepartment of Surgery and the First Surgical Service of the University Hospital, University of Washington School of Medicine, Seattle, Washington, U.S.A.

J.-M. Limbosch

J. H. WyllieDepartment of Surgery and the First Surgical Service of the University Hospital, University of Washington School of Medicine, Seattle, Washington, U.S.A.

M. J. RheaultDepartment of Surgery and the First Surgical Service of the University Hospital, University of Washington School of Medicine, Seattle, Washington, U.S.A.

L. M. NyhusDepartment of Surgery and the First Surgical Service of the University Hospital, University of Washington School of Medicine, Seattle, Washington, U.S.A.;Department of SurgeryUniversity of Washington School of MedicineSeattle, Washington, U.S.A.

, M.D

Abstract

Calcium salts were infused against a background of stimulation by histamine or porcine gastrin or against the release of endogenous gastrin (feeding test). Raising the plasma calcium to values noted in clinical chronic hyperparathyroidism did not influence histamine-stimulated secretion but had a strong inhibitory action on gastrin-stimulated secretion. In the feeding tests (endogenous gastrin) the onset of secretion was delayed by calcium infusion.

The results of these experiments cannot be related directly to the problem of hyperparathyroidism, hypercalcemia, and peptic ulcer. The results do, however, indicate a difference in the stimulant actions of gastrin and histamine.

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Effects of Calcium Infusion on Gastric Secretion in Heidenhain Pouch Dogs

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Effects of Calcium Infusion on Gastric Secretion in Heidenhain Pouch Dogs

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