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Original Articles

Hepatic Histological Changes in Ulcerative Colitis

A series of 58 consecutive operative liver biopsies

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Pages 220-227 | Received 10 Oct 1966, Published online: 29 Nov 2016
 

Abstract

Operative liver biopsy was performed on 58 consecutive patients coming to radical excisional surgery for ulcerative colitis.

The histological changes seen in the liver were: increased cellularity of the portal tracts (83 per cent); fatty infiltration (83 per cent); areas of focal necrosis (47 per cent); and early cirrhosis (2 per cent).

Severe liver damage was shown to he associated with severe active colitis, and with a poor subsequent post-operative prognosis. The mechanisms responsible for liver damage in patients with colitis are discussed.

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