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Abstract
Aune, S. 1970. Transperitoneal Exchange. III. The Influence of Transperitoneal Fluid Flux on the Peritoneal Plasma Clearance of Serum Albumin in Rabbits. Scand. J. Gastroent. 5, 161-168.
The appearance of serum albumin in the peritoneal cavity has been estimated, collecting peritoneal fluid under conditions allowing measurement of the filtration rate as well as the relative albumin concentration in the filtrate. On average, resting influx of peritoneal fluid was 0.13 ml/min, and albumin concentration compared to serum was 0.50, which means a transperitoneal albumin clearance of 0.065 ml/min. Increased fluid filtration resulted in a significant enhancement of transperitoneal albumin clearance. The results are compatible with the pore theory of Pappenheimer et al. (1951) on the assumption that one-third of the area available for water is also passable for serum albumin. If the pores are cylindrical, the pore radius is calculated as 120 Å, giving the picture of a rather leaky membrane.