The Effect of Experimental Cholestasis on the Negative Feedback Regulation of Cholesterol Synthesis in Rat Liver

Abstract

Kattermann, R. & Creutzfeldt, W. 1970. The Effect of Experimental Cholestasis on the Negative Feedback Regulation of Cholesterol Synthesis in Rat Liver. Scand. J. Gastroent. 5, 337-342.

The incorporation rate of 2-¹¹-C-acetate into cholesterol was measured in liver slices of cholesterol-fed and bile-duct-ligated rats. The negative feedback inhibition of cholesterol biosynthesis was abolished by cholestasis. The incorporation rate increased about 10-fold above control values, even if absorption of exogenous cholesterol was restored by addition of bile salts.

Key-words:

• Bile-duct ligation
• cholestasis
• cholesterol biosynthesis
• lipid metabolism
• negative feedback regulation