Bioassay for Gastric Secretory Inhibitor in Extract of Pancreatic Tumour from Patient with WDHA-Syndrome

L. S. SembInstitute for Experimental Medical Research, University of Oslo, Ullevål Hospital, Oslo, Medical Dept A, University Hospital, Rikshospitalet, Oslo, Norway, and Dept. of Medicine, New York Medical College, New York, N. Y., USA

E. GjoneInstitute for Experimental Medical Research, University of Oslo, Ullevål Hospital, Oslo, Medical Dept A, University Hospital, Rikshospitalet, Oslo, Norway, and Dept. of Medicine, New York Medical College, New York, N. Y., USA

W. S. RosenthalInstitute for Experimental Medical Research, University of Oslo, Ullevål Hospital, Oslo, Medical Dept A, University Hospital, Rikshospitalet, Oslo, Norway, and Dept. of Medicine, New York Medical College, New York, N. Y., USA

Abstract

Semb, L. S., Gjone, E. & Rosenthal, W. S. 1970. Bioassay for Gastric Sccretory Inhibitor in Extract of Pancrcatic Tumour from Patient with WDHA-Syndrome. Scand. J. Gastroent. 5, 409-414.

Pancreatic tumour tissue from a patient with WDHA-syndrome was extracted according to methods for separating gastrone. Heidenhain pouch dog experiments showed significant inhibitory activity on the continuous i. v. histamine-stimulated gastric secretion when fractions 1 and 4 were given i. v (50 |ig/kg bw). Mucosal blood flow followed the sccretory pattern. No blood glucose changes took place. No secretory response from pancreas occurred. The tumour tissue thus exerts a gastronc-like activity that may explain main features of the WDHA syndrome.

Key-words:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Bioassay for Gastric Secretory Inhibitor in Extract of Pancreatic Tumour from Patient with WDHA-Syndrome

Information for

Open access

Opportunities

Help and information

Bioassay for Gastric Secretory Inhibitor in Extract of Pancreatic Tumour from Patient with WDHA-Syndrome

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature