Gastric Secretion of Hydrochloric Acid and Sialic Acid in Patients with Peptic Ulcer and Gastric Cancer during Intravenous Infusion of Histamine

Abstract

Carlborg, L., Dahlgren, S. & Nordgren, B. 1970. Gastric Secretion of Hydrochloric Acid and Sialic Acid in Patients with Peptic Ulcer and Gastric Cancer during Intravenous Infusion of Histamine. Scand. J. Gastroent. 5, 427-431.

Normal subjects and patients with peptic ulcer and gastric cancer were examined with a histamine infusion test. The dynamic changes in production of HC1 and mucosa-protecting mucoid were studied. The mucus was estimated by its content of sialic acid (SA). In normal subjects the histamine stimulation resulted in an increase in the concentration of HC1, concomitant with an initially decreased concentration of SA, followed by a late compensatory increased concentration of SA. This response occurred infrequently in ulcer patients. In patients with gastric cancer the output of SA was continuously high and the acidity low.

Key-words:

• Duodenal ulcer
• gastric juice
• gastric mucin
• neuramic acids
• stomach, neoplasms
• stomach ulcer