The Secretion of Intrinsic Factor in Patients with Chronic Gastritis

Abstract

Rödbro, P., Christiansen, P. M. & Johansen, Å. 1970. The Secretion of Intrinsic Factor in Patients with Chronic Gastritis. Scand. J. Gastroent. 5, 465-471.

Intrinsic factor (IF) secretion was studied in 73 patients (with low or abolished acid secretion) who also had a gastric biopsy. The IF secretion declined significantly with increasing severity of the mucosal lesion. The mean values (in kilo-units/hour) after augmented histamine stimulation were: 10.6 (superficial gastritis); 7.9 (atrophic gastritis with acid secretion); 2.1 (hypo-achlor-hydria). In patients with pernicious anaemia the IF output in all cases was below 0.2, showing no overlap with achlorhydric patients without pernicious anaemia.

Key-words:

• Gastric acidity determination
• gastric biopsy
• gastric juice
• gastric mucosa
• gastritis
• intrinsic factor
• pernicious anaemia