Influence of Cholestyramine, Bile Salt, and Cholesterol Feeding on the Lipid Composition of Hepatic Bile in Man

Abstract

Sarles, H., Crotte, C., Gerolami, A., Mule, A., Domingo, N. & Hauton, J. 1970. Influence of Cholestyramine, Bile Salt, and Cholesterol Feeding on the Lipid Composition of Hepatic Bile in Man. Scand. J. Gastroent. 5, 603-608.

A patient with a T-tube in the main bile duct was given a controlled diet 21 days after cholecystectomy. Neither the cholesterol composition of the diet nor the daily intake of 50 ml pure ethanol had any effect on biliary concentrations of cholesterol, bile salts and phospholipids. 10 g cholestyramine daily produced a marked decrease in bile salts, but a lesser reduction in cholesterol, thus probably favoring cholesterol crystal-formation. The effect of 600 mg bile salts daily might have been mainly due to an acceleration in intestinal transit time. It was not favorable to cholesterol solubilization.

Key-words::

• Bile salts
• cholesterol
• cholestyramine
• diet
• ethanol
• gallstones
• hepatic bile
• phospholipids