Examination of the Inflammatory Reaction in Ulcerative Colitis by Use of the Skin-Window Technique

Abstract

Binder, Vibeke & Riis, P. 1970. Examination of the Inflammatory Reaction in Ulcerative Colitis by Use of the Skin-Window Technique. Scand. J. Gastroent. 5, 641-645.

By employing the skin-window technique, the effect of intradermal injection of autologous colonic mucosa homogenate was examined in 20 patients with ulcerative colitis and in 6 controls. A simultaneous injection of isotonic saline into a control skin window was given to all the patients. Twelve of the 20 patients developed an inflammatory picture consisting in the occurrence of basophil granulocytes in the second 24-hour examination period. This picture was seen both after injection of colon homogenate and of isotonic saline. The patients with basophilia did not differ from the other patients with respect to sex, age, duration, and activity of the disease, allergic disposition, and occurrence of extracolonic manifestations.

Key-Words::

• Basophils
• colitis, ulcerative
• inflammation