The Effect of a Ganglion-blocking Agent (Hexamethonium Bromide) upon the Secretory Response to Feeding in Dogs with Selective Vagotomy of the Parietal Cell Mass

Abstract

Amdrup, B. M. & Griffith, C. A. 1970. The Effect of a Ganglion-blocking Agent (Hexamethonium Bromide) upon the Secretory Response to Feeding in Dogs with Selective Vagotomy of the Parietal Cell Mass. Scand. J. Gastroent. 5, 667-674.

Feeding response in Heidenhain pouch dogs with selective vagotomy of the parietal cell mass with and without suprapyloric antrectomy was compared to feeding response during treatment with hexamethonium bromide. The effect of hexamethonium was initial inhibiton of pouch secretion, followed by delayed hypersecretion. The inhibition may result from blockage of vagal stimulation of the antrum. The reason for the delayed hypersecretion is discussed.

Key-words::

• Feeding response
• ganglion blockage
• gastric secretion
• hexamethonium bromide
• parietal cell mass
• vagotomy