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Abstract
Sarles, H., Tiscornia, O., Palasciano, G., Brasca, A., Hage, G., Devaux, M. A. & Gullo, L. 1973. Effects of Chronic Intragastric Ethanol Administration on Canine Exocrine Pancreatic Secretion. Scand. J. Gastroent 8, 85-96.
The effect of an acute intravenous infusion of 1.3 g/kg of ethanol superimposed on a prolonged infusion of either 1.0 U/kg/h of secretin or 1.0 U/kg/h secretin + 3.0 U/kg/h CCK has been studied in 6 dogs provided with Thomas cannulae before and at the 6th and 14th week of a daily intragastric administration of 2.0 g ethanol, (a) Increased response to CCK stimulation is the main feature of pancreatic gland subjected to chronic intragastric ethanol administration, (b) Chronic alcoholism abolished the previously described inhibitory action on pancreatic secretion of acute intravenous ethanol, (c) Microcalculi (rich in calcium) and protein plugs were excreted during chronic alcoholism.