Cyclic 3′,5′-Adenosine Monophosphate in the Rat Gastric Mucosa after Starvation, Feeding, and Pentagastrin

Abstract

Ruoff, H.-J. & Sewing, K.-Fr. 1973. Cyclic 3′,5′-Adenosine Monophosphate in the Rat Gastric Mucosa after Starvation, Feeding, and Pentagastrin. Scand. J. Gastronet. 8, 241-243.

The effect of starvation, feeding, and pentagastrin on the cyclic 3′. 5′-adenosine monophosphate content in the rat gastric mucosa was investigated. The cyclic 3′,5′-AMP concentration of normally fed rats was 0.87 ± 0.04 nmol/g mucosa and dropped significantly after a starvation period of 48 hours to 0.62 ± 0.06 nmol/g. Refeeding of starved rats did not change the cyclic 3′,5′-AMP level within two hours. Pentagastrin caused an increase of the ‘second messenger’ to a maximum of 1.19 ± 0.06 nmol/g mucosa within one hour after the injection. The changes are likely to be caused by alteration of the adenyl cyclase activity.

Key-words::

• Cyclic 3′,5′-adenosine monophosphate
• feeding
• pentagastrin
• rats
• starvation