Gastric Secretory Relationship between H⁺ and Pepsin in Fistula Chickens

Abstract

Burhol, P. G. 1973. Gastric Secretory Relationship between H⁺ and Pepsin in Fistula Chickens. Scand. J. Gastroent. 8, 283-288.

Pentagastrin in doses of 75, 150, 300 and 600 μg/kg-hr was infused subcutaneously for 120 min on separate days to each of 14 Plymouth Rock chickens with surgically implanted proventricular cannulas. Steady state gastric secretion was achieved. Gastric H^H and pepsin followed each other rather closely, as also indicated by closely similar secretory kinetics. Pentagastrin was found to shift the ratio of pepsin to H* secretion from one level to a higher one, and so to show an unusually strong pepsigogue effect. It is concluded that the gastric H⁺ and pepsin secretion is more closely related in birds than in mammals.

Key-words::

• Chicken
• H⁺ kinetics
• pentagastrin
• pepsin