Phenylbutazone Ulcer and Vagotomy in the Rat

Abstract

Larmi, T. K. I & Kairaluoma, M. I. 1973. Phenylbutazone Ulcer and Vagotomy in the Rat. Scand. J. Gastroenl. 8, 307-311.

Phenylbutazone, 200 mg/kg intramuscularly, produced glandular ulcers within 6 hours without mortality in 90 % of the rats treated. When the dose was raised to 250 mg/kg i.m., the mortality was considerable. The ulcer formation correlated with the duration of the phenylbutazone action: the longer the animals were followed up within the observation period of 6 hours, the more severe was the ulcer disease. The method was easy to standardize, simple and quick. The incidence of the ulcers was highest in the corpus part of the stomach. The ulcer crater was always covered by a digested blood coagulum. The antral ulcers developed later and were less severe. Vagotomy inhibited completely the formation of phenylbutazone ulcers. The animals vagotomized one week earlier tolerated phenylbutazone poorly. The ulcerogenic action of phenylbutazone cannot be direct local erosion through the mucosa, at least not exclusively.

Key-words::

• Gastric ulcer
• peptic ulcer
• phenylbutazone
• stomach
• vagotomy