Intragastric Pressure, Secretagogue Characteristics, and Pathogenesis of Phenylbutazone Ulcer

Abstract

Larmi, T. K. I. & Kairaluoma, M. I. 1973. Intragastric Pressure, Secretagogue Characteristics, and Pathogenesis of Phenylbutazone Ulcer. Scand. J. Gastroent. 8, 317-320.

Intramuscular injection of 200 mg/kg of phenylbutazone reduced significantly the volume of gastric secretion, intragastric pressure, and acid secretion in the rat, yet induced ulcers in the corpus part of the stomach of about 50 % of the experimental animals in 2 hours. Pyloric ligation did not increase the ulcer formation induced by phenylbutazone. When pyloric ligation and vagotomy were performed simultaneously on rats treated with phenylbutazone, gastric secretion fell to almost zero while intragastric pressure rose to almost the level seen in the Shay rat. Despite the increase in pressure, no ulcers developed. Hence a certain acidity of the gastric juice is necessary for ulcer formation. However, the hydrochloric acid secretion of the stomach was not the dominating factor in the pathogenesis of the phenylbutazone ulcer.

Key-words::

• Gastric secretion
• gastric ulcer
• intragastric pressure
• pathogenesis of phenylbutazone ulcer
• phenylbutazone
• stomach
• vagotomy