Biliary Lipid Composition in Normolipidemic and Prebeta Hyperlipoproteinemic Gallstone Patients

Abstract

Cahlin, E., Jönsson, Jane, Nilsson, S. & Scherstén, T. 1973. Biliary Lipid Composition in Normolipidemic and Prebeta Hyperlipoproteinemic Gallstone Patients. Influence of Sucrose Feeding of the Patient on the Biliary Lipid Composition. Scand. J. Gastroent. 8, 449-456.

Hepatic bile lipid composition was analyzed in patients with and without gallstone disease. Gallstone patients had significantly lower concentration of bile acids and lecithins in hepatic bile, but the cholesterol concentration was the same as in gallstone-free patients. In prebeta hyperlipoproteinemic gallstone patients the concentration of chenodeoxycholic acid was very low, and the concentration of total bile acids and lecithins significantly decreased as compared with both gallstone-free patients and normolipidemic gallstone patients. Gallstone patients with functioning gallbladder had higher biliary cholesterol concentration than the gallstone patients with non-functioning gallbladder. It is concluded that the number and rate of enterohepatic circula-tion of bile acids are of great importance for the lithogenic potential of hepatic bile. It is suggested that the comparatively high prevalence of gall-stone disease in patients with prebeta hyperlipoproteinemia is dependent on a lipid metabolic defect in the liver.

Key-words::

• Bile acids
• cholesterol
• gallstone
• hyperlipoproteinemia
• lecithin
• lipids