Metabolie Clearance and Disappearance Rates of Synthetic Human Gastrin in Man

Abstract

Schrumpf, E., Semb, L. S. & Void, H. Metabolie clearance and disappearance rates of synthetic human gastrin in man. Scand. j. Gastroent. 1973, 8, 731-734.

Synthetic human gastrin (SHG) was infused at a constant rate for 2 hours in 5 volunteers. The concentration of gastrin was determined by radio-immunoassay in plasma samples before, during, and at frequent intervals after the infusion. The gastric acid output was also measured. During the infusion the gastrin concentration and the gastric acid output reached a plateau level. After stopping the infusion a rapid decline in the plasma con-centration of gastrin was observed. Regression analysis indicated that the dis-appearance curve was at least bi-exponential, which means that the removal of gastrin is not proportional to the concentration. The mean metabolic clearance rate (MCR) per kg bodyweight was found to be 9.1 ml/min. MCR of SHG in this study is considerably smaller than previously found in the dog, suggesting that heterologous gastrin is broken down more rapidly than homologous gastrin.

Key-words::

• Gastric secretion
• gastrin
• half-life
• metabolism