Stimulation by 2-Deoxy-D-Glucose and Inhibition by Insulin of Gastric Secretion in Fistula Chickens

Abstract

Burhol, P. G. Stimulation by 2-deoxy-D-glucose and inhibition by insulin of gastric secretion in fistula chickens. Scand. J. Gastroent. 1973, 8, 761-764.

The effect of intravenous injection of 2-deoxy-D-glucose and insulin on basal gastric secretion was studied in 10 fistula chickens. As might be anticipated from the unusually high blood sugar in the chicken, a higher dose of 2-deoxy-D-glucose and more time after its administration were required to raise their gastric water, H+, and pepsin secretion significantly than in mam-mals. It is concluded that the gastric secretion in the chicken is subject to vagal stimulation. Insulin, on the other hand, showed a dose-dependent and significant inhibition of the gastric secretion of water and H+, but not of pepsin secretion. It would appear therefore that insulin inhibits the gastric secretion by a direct action on the gastric transport of water and H⁺. It is concluded that fistula chickens can be used as a model to study the inhibitory effect of insulin unopposed by any central stimulatory effect.

Key-words::

• Chickens
• 2-deoxy-D-glucose
• inhibition
• insulin
• pepsin
• vagal stimulation
• water and H⁺ transport