Gastric Stimulation by Intravenous Injection of Cholecystokinin and Secretin in Fistula Chickens

Abstract

Burhol, P. G. Gastric stimulation by intravenous injection of cholecystokinin and secretin in fistula chickens. Scand. J. Gastroent. 1974, 9, 49–53.

The effect of intravenous injection of cholecystokinin and secretin on gastric secretion was studied in 10 fistula chickens. Cholecystokinin elicited a significant, dose-dependent and fivefold rise in the gastric H+ secretion, whereas the pepsin secretion showed a slight and not significant rise. It is suggested that cholecystokinin compared with pentagastrin may be a full agonist for stimulation of gastric H⁺ and a partial agonist for stimulation of pepsin secretion in the chicken. Secretin caused, on the other hand, a significant, dose-dependent and some threefold increase both in the gastric H⁺ and the pepsin secretion. It is proposed that secretin stimulates the gastric secretion in the chicken by a direct action on the gastric mucosa. The possibility that the intestinal phase may be more important in the physiological stimulation of the gastric secretion in birds than in mammals is discussed.

Key-words::

• Chicken
• cholecystokinin
• H⁺
• intestinal phase
• pepsin
• secretin
• stimulation