Effects of Cholecystokinin, Secretin, 2-Deoxy-D-Glucose and Insulin on Pentagastrin-Stimulated Gastric Secretion in Fistula Chickens

Abstract

Burhol, P. G. Effects of cholecystokinin. secretin. 2-deoxy-D-glucose and insulin on pentagastrin-stimulated gastric secretion in fistula chickens. Scand. J. Gastroent. 1974, 9, 55–58.

The effect of cholecystokinin. secretin, 2-deoxy-D-glucose and insulin on pentagastrin-stimulated gastric secretin was studied in 14 fistula chickens. Cholecystokinin elicited a brief but significant rise in the gastric water and H⁺ secretion, whereas it showed a sustained and significant inhibition of the pepsin secretion. Secretin also temporarily raised the gastric secretion of water significantly. A similar tendency could also be discerned for gastric H⁺ and pepsin secretion, though their changes were not statistically significant. 2-deoxy-D-glucose showed a late but significant increase in the gastric water and H⁺ secretion. Pepsin secretion also behaved similarly, though its rise was not statistically significant. Insulin caused a sustained and significant inhibition not only of gastric water and H⁺ but of pepsin secretion as well. The present findings are discussed to get some preliminary ideas about the interaction between these drugs and pentagastrin in the chicken.

Key-words::

• Chickens
• cholecystokinin
• 2-deoxy-D-glucose
• drug interaction
• insulin
• pentagastrin
• secretin