The Effects of Thyrocalcitonin on Gastric Acid Secretion in Intact and Thyroidectomized Thyroxin-Substituted Gastric Fistula Cats

Abstract

Nordgren, C.-E., Nyhus, L. M. & Bombeck, C. T. The effects of thyrocalcitonin on gastric acid secretion in intact and thyroidectomized thyroxin-substituted gastric fistula cats. Scand. J. Gastroent. 1974, 9, 103–109.

A single injection of thyrocalcitonin was found to inhibit gastric secretion in the chronic fistula cat stimulated by 2-Deoxy-D-Glucose injections as well as by constant infusions of pentagastrin and histamine in submaximal doses. Thyroidectomized as well as intact cats were studied and both groups showed similar responses to gastric stimulants. Thyrocalcitonin inhibited gastric secretion briefly in both groups, and there was an additional late inhibition of gastrin- and histamine-stimulated secretion in the thyroidectomized animals. A small dose of thyrocalcitonin did not inhibit pentagastrin-stimulated secretion in the thyroidectomized cats. No significant change in serum calcium concentration was observed.

Key-words::

• 2-Deoxy-D-Glucose
• gastric secretion
• histamine
• pentagastrin
• thyrocalcitonin