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Abstract
Schrumpf, E. & Myren, J. Effect of atropine on plasma concentration of gastrin in fasting subjects. Scand. J. Gastroent. 1974, 9, 123–125.
The effect of atropine on the basal gastrin level, acid secretion, and gastric pH in 5 normals, and also the effect of atropine on the basal gastrin level in 8 achlorhydric patients has been determined. In the normals a considerable decrease in gastric acid output was found concomitantly with an elevation of pH of the gastric juice. There was, however, no change in the gastrin concentration, demonstrating that the decrease in gastric acid output after atropine is not due to inhibition of gastrin release. In the achlorhydric patients a significant decrease in plasma gastrin concentration was observed after atropine. suggesting a cholinergic influence on basal gastrin release in these patients.
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