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Abstract
Stadaas, J., Schrumpf, E. & Haffner, J. F. W. The effect of gastric distention on gastric motility and serum gastrin in acutely vagotomized pigs. Scand. J. Gastroent. 1974, 9, 127–131.
Gastric motility and gastrin release after stepwise gastric distention were measured before and after vagotomy in pigs. Motility recordings were obtained separately from antral and fundal parts of the stomach by sectioning the organ. The effects of gastric distention were significantly altered after vagal denervation. Both increases in serum gastrin and antral peristalsis diminished after vagotomy. Basal pressure increments were more marked in antral as well as fundal parts of the stomach, and fundal and antral adaptation times were prolonged after vagal denervation. It is concluded that vagotomy alters motility both in distal and proximal parts of the stomach, indicating that even proximal gastric vagotomy produces changes in gastric motor function. It is also concluded that intact antral innervation is necessary for normal gastrin release after distention.