Acid Response to Graded Doses of Pentagastrin and Feeding, and Effect of Atropine in Heidenhain Pouch Cats

Abstract

Svensson, S.-O. & Emâs, S. Acid response to graded doses of pentagastrin and feeding, and effect of atropine in Heidenhain pouch cats. Scand. J. Gastroent. 1974, 9, 281-286.

In cats with both gastric fistulas (GF) and Heidenhain pouches (HP), the maximum of the dose-response curve for HP acid output (GF closed) to graded doses of i.v. pentagastrin was higher than the maximum to graded meat meals. The maximal response to feeding amounted to 70 per cent of that to pentagastrin. Atropine (0.1 mg per kg i.v.) prior to stimulation markedly reduced the maximal response to feeding but did not alter an equally high response to pentagastrin. This could mean that endogenous gastrin was more susceptible than pentagastrin to inhibition by atropine at the parietal cells, or atropine inhibited the release of gastrin, or both. The HP acid response to 2-deoxy-D-glucose (2DG, 100 mg per kg i.v., GF open) amounted to 1/5th—1/6th of the maximal response to feeding (GF closed), suggesting that feeding released more gastrin than vagal stimulation (2DG) alone.

Key-words::

• Atropine
• 2-deoxy-D-glucose
• feeding
• gastric acid secretion
• pentagastrin