The Effect of Glucagon on Pentagastrin-Induced Gastric Secretion of Sodium, Potassium, and Calcium in Man

Abstract

Christiansen, J. & Hendel, L. The effect of glucagon on pentagastrin-induced gastric secretion of sodium, potassium, and calcium in man. Scand. J. Gastroent. 1974, 9, 437–440.

The effect of glucagon on gastric secretion of Na, K, and Ca was studied in 7 healthy individuals. Glucagon (20 µg/kg-hr) was administered as a continuous intravenous infusion on a background infusion of pentagastrin (1 µg/ kg-hr). Sodium output was reduced, but the ratio Na concentration/secretory rate increased, indicating a relative increase in sodium output. Potassium secretion was significantly inhibited. Calcium concentration increased slightly, and output was inhibited to the same degree as volume secretion.

Key-words::

• Calcium
• gastric secretion
• glucagon
• potassium
• sodium